Enantioselective Hydrogenation of Activated Ketones Using Heterogeneous Pt Catalysts Modified with Cinchona Alkaloids

The enantioselective reduction of ketones in general and of functionalized ketones in particular is of high interest, both from an academic and industrial point of view.

The most effective methods available today are hydride reductions using both stoichiometric and catalytic amounts of chiral auxiliaries,

various biocatalytic methodologies,

catalytic transfer hydrogen,

and catalytic hydrogenation.