ABSTRACT
I. Introduction .................................................................................................................... 265
II. HA/Collagen Composite as Bone Substitute ................................................................. 265
III. Biomimetic HA/Collagen Scaffold ................................................................................ 267
IV. Challenges and Perspectives .......................................................................................... 270
References ................................................................................................................................... 271
Bone regeneration through tissue engineering is one of the important focuses of research in a wide
variety of areas including orthopedic, craniofacial, maxillofacial research, and dentistry. It may
provide a promising alternative for clinical practices to overcome the inherent limitations of the
currently available solutions for bone reconstruction surgery. The challenging situations are those
severe traumatic or degenerative skeletal problems where massive bone loss or complicated
defect occurs.
