ABSTRACT
In this chapter, we will discuss general concepts and expressions associated
with microfluidic separation systems. Our discussion will begin with a de-
scription of a basic microfluidic device and include examples of electroki-
netic and pressure-driven methods for transporting fluids through these
devices. Our attention will then turn to separation efficiency, resolution, and
peak capacity followed by a discussion of the contributions to analyte disper-
sion in microfluidic separations. The chapter will then discuss microfluidic
devices as equivalent electrical circuits, and how this circuit analogy applies
to mixing and valving on microfluidic devices. The chapter will conclude
with scaling of separations that are limited by the injection plug length.
