ABSTRACT
I. Introduction ...................................................................................................................... 931
II. sMMO Components ......................................................................................................... 932
III. sMMO Catalytic Cycle .................................................................................................... 933
IV. Kinetic Solvent Isotope Effect used to Probe Proton Donors......................................... 936
V. The Mechanism of Q Reaction with Substrates.............................................................. 938
VI. Arrhenius Plots for the Reactions of Reaction Cycle Intermediates .............................. 942
VII. The Effects of MMOB..................................................................................................... 943
VIII. A Test of the Molecular-Sieve Model using KIE Studies .............................................. 945
IX. A Tunneling Reaction ...................................................................................................... 946
X. New Insight into the Mechanism of C-H Bond Cleavage............................................. 947
Acknowledgments ........................................................................................................................ 949
References..................................................................................................................................... 949
Methanotrophic bacteria exist by using methane as a sole source of carbon and energy.