ABSTRACT
What is Nutrigenomics? 1
Do Oxidants and Antioxidants Affect Gene Expression? 3
Methods and Applications in Nutrigenomics 4
References 9
WHAT IS NUTRIGENOMICS?
The rapid progress in the understanding of the human genome has opened up
new avenues to study interactions between diet, gene expression, genetic varia-
bility, health, and disease. Nutrigenomics considers the relationship between
specific nutrients or diet and gene expression (1), whereas nutrigenetics deter-
mines how genetic variability affects the response to diet (2). Nutrigenomics
is a modern discipline at the interface between genetics, molecular nutrition,
molecular biology, pharmacogenomics, and molecular medicine (Fig. 1.1).
Nutrigenomics applies high-throughput molecular biology techniques inclu-
ding sequencing and genotyping (genomics), transcriptomics, proteomics, and
metabolomics.
