ABSTRACT
In this chapter the generation of free radicals, mainly superoxide and nitric oxide, catalyzed
by ‘‘prooxidant’’ enzymes will be considered. Enzymes are apparently able to produce some
other free radicals (for example, HO . and
. NO2), although their formation is not always
rigorously proved or verified. The reactions of such enzymes as lipoxygenase and cyclooxy-
genase also proceed by free radical mechanism, but the free radicals formed are consumed in
their catalytic cycles and probably not to be released outside. Therefore, these enzymes are
considered separately in Chapter 26 dedicated to enzymatic lipid peroxidation.
