ABSTRACT
Although the first manifestations of hydrogen peroxide formation by mitochondria [1,2] have
been taken with caution, the following studies [3,4] confirmed these findings. It has been
reasonable to suggest that hydrogen peroxide could be a product of superoxide dismutation
and that superoxide is produced by mitochondria. Such proposal was indeed confirmed by
Loschen et al. [5] and Boveris and Cadenas [6], who showed that hydrogen peroxide is a
stoichiometric precursor of mitochondrial hydrogen peroxide.
