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(Continued) Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F SEQUENCE 1 43 0.33 0.5672 PERIOD 1 43 0.29 0.5947 FORM 1 43 1.06 0.3080 Estimates Standard Label Estimate Error ABE for logAUC 0.09699 0.09401 DF t Value Pr > |t| 43 1.03 0.3080 Least Squares Means Standard Effect FORM Estimate Error FORM R 4.4143 0.1970 FORM T 4.5113 0.1970 Differences of Least Squares Means Effect FORM _FORM Estimate FORM R T -0.09699 DF t Value Pr > |t| Alpha 43 -1.03 0.3080 0.1 Standard Error 0.09401 Differences of Least Squares Means Effect FORM _FORM Lower Upper FORM R T -0.2550 0.06104 The 90% confidence interval for µ is (−0.0610,0.2550) for log(AUC) and (−0.0871,0.1887) for log(Cmax), where it will be noted that the signs have been reversed compared to those in the SAS output. Exponentiating the limits to obtain confidence limits for exp(µ ), gives (0.9408,1.2905) for AUC and (0.9166,1.2077) for Cmax. A graph-ical summary of these results is given in Figure 7.3. Here, to show the overall pattern and the essential details, we have plotted all the T/R ratios in the left plot and only those ratios which are less than 2.5 in the right plot. Also given in the plots are the
DOI link for (Continued) Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F SEQUENCE 1 43 0.33 0.5672 PERIOD 1 43 0.29 0.5947 FORM 1 43 1.06 0.3080 Estimates Standard Label Estimate Error ABE for logAUC 0.09699 0.09401 DF t Value Pr > |t| 43 1.03 0.3080 Least Squares Means Standard Effect FORM Estimate Error FORM R 4.4143 0.1970 FORM T 4.5113 0.1970 Differences of Least Squares Means Effect FORM _FORM Estimate FORM R T -0.09699 DF t Value Pr > |t| Alpha 43 -1.03 0.3080 0.1 Standard Error 0.09401 Differences of Least Squares Means Effect FORM _FORM Lower Upper FORM R T -0.2550 0.06104 The 90% confidence interval for µ is (−0.0610,0.2550) for log(AUC) and (−0.0871,0.1887) for log(Cmax), where it will be noted that the signs have been reversed compared to those in the SAS output. Exponentiating the limits to obtain confidence limits for exp(µ ), gives (0.9408,1.2905) for AUC and (0.9166,1.2077) for Cmax. A graph-ical summary of these results is given in Figure 7.3. Here, to show the overall pattern and the essential details, we have plotted all the T/R ratios in the left plot and only those ratios which are less than 2.5 in the right plot. Also given in the plots are the
(Continued) Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F SEQUENCE 1 43 0.33 0.5672 PERIOD 1 43 0.29 0.5947 FORM 1 43 1.06 0.3080 Estimates Standard Label Estimate Error ABE for logAUC 0.09699 0.09401 DF t Value Pr > |t| 43 1.03 0.3080 Least Squares Means Standard Effect FORM Estimate Error FORM R 4.4143 0.1970 FORM T 4.5113 0.1970 Differences of Least Squares Means Effect FORM _FORM Estimate FORM R T -0.09699 DF t Value Pr > |t| Alpha 43 -1.03 0.3080 0.1 Standard Error 0.09401 Differences of Least Squares Means Effect FORM _FORM Lower Upper FORM R T -0.2550 0.06104 The 90% confidence interval for µ is (−0.0610,0.2550) for log(AUC) and (−0.0871,0.1887) for log(Cmax), where it will be noted that the signs have been reversed compared to those in the SAS output. Exponentiating the limits to obtain confidence limits for exp(µ ), gives (0.9408,1.2905) for AUC and (0.9166,1.2077) for Cmax. A graph-ical summary of these results is given in Figure 7.3. Here, to show the overall pattern and the essential details, we have plotted all the T/R ratios in the left plot and only those ratios which are less than 2.5 in the right plot. Also given in the plots are the
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