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and the concentration of drug in the blood increases. After the tablet has been dissolved the rate of elimination is greater and the concentration declines. A typical shape for the drug concentration over time is given in Figure 7.5. An appropriate one-compartment model for the shape of plot in Figure 7.5 might be k − − ) C = e (7.19) V (k ) where d is dose, t is time and C is the volume of distribution (litres) that converts total drug dose in the compartment into concentration. The absorption and elimination rate parameters (hr ) are k , respectively. Because it has been observed in practice that the amount of variability in the concentrations seems to be dependent on the size of the mean con-
DOI link for and the concentration of drug in the blood increases. After the tablet has been dissolved the rate of elimination is greater and the concentration declines. A typical shape for the drug concentration over time is given in Figure 7.5. An appropriate one-compartment model for the shape of plot in Figure 7.5 might be k − − ) C = e (7.19) V (k ) where d is dose, t is time and C is the volume of distribution (litres) that converts total drug dose in the compartment into concentration. The absorption and elimination rate parameters (hr ) are k , respectively. Because it has been observed in practice that the amount of variability in the concentrations seems to be dependent on the size of the mean con-
and the concentration of drug in the blood increases. After the tablet has been dissolved the rate of elimination is greater and the concentration declines. A typical shape for the drug concentration over time is given in Figure 7.5. An appropriate one-compartment model for the shape of plot in Figure 7.5 might be k − − ) C = e (7.19) V (k ) where d is dose, t is time and C is the volume of distribution (litres) that converts total drug dose in the compartment into concentration. The absorption and elimination rate parameters (hr ) are k , respectively. Because it has been observed in practice that the amount of variability in the concentrations seems to be dependent on the size of the mean con-
ABSTRACT