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as the subjects. In a 2 × 2 trial, for example, each subject is given a single dose of T and R and blood samples are taken at a series of time points subsequent to dosing. Each blood sample is then assayed to de-termine the concentration of drug in the blood plasma. Often the blood sampling is taken more frequently during what is expected to be the absorption phase of the drug and then less frequently during the elimi-nation phase. For each subject and period the concentrations of drug in the blood are plotted against the corresponding sampling times to give a concentration-time profile for that subject and period. A typical profile is given in Figure 7.1. Once the drug gets past the stomach and into the small intestine it begins to be absorbed into the blood, eventually reaching a peak con-centration. From then on the concentration diminishes as the drug is eliminated from the body. The area under the profile is referred to as
DOI link for as the subjects. In a 2 × 2 trial, for example, each subject is given a single dose of T and R and blood samples are taken at a series of time points subsequent to dosing. Each blood sample is then assayed to de-termine the concentration of drug in the blood plasma. Often the blood sampling is taken more frequently during what is expected to be the absorption phase of the drug and then less frequently during the elimi-nation phase. For each subject and period the concentrations of drug in the blood are plotted against the corresponding sampling times to give a concentration-time profile for that subject and period. A typical profile is given in Figure 7.1. Once the drug gets past the stomach and into the small intestine it begins to be absorbed into the blood, eventually reaching a peak con-centration. From then on the concentration diminishes as the drug is eliminated from the body. The area under the profile is referred to as
as the subjects. In a 2 × 2 trial, for example, each subject is given a single dose of T and R and blood samples are taken at a series of time points subsequent to dosing. Each blood sample is then assayed to de-termine the concentration of drug in the blood plasma. Often the blood sampling is taken more frequently during what is expected to be the absorption phase of the drug and then less frequently during the elimi-nation phase. For each subject and period the concentrations of drug in the blood are plotted against the corresponding sampling times to give a concentration-time profile for that subject and period. A typical profile is given in Figure 7.1. Once the drug gets past the stomach and into the small intestine it begins to be absorbed into the blood, eventually reaching a peak con-centration. From then on the concentration diminishes as the drug is eliminated from the body. The area under the profile is referred to as
ABSTRACT