ABSTRACT

The ultimate goal of the genomic revolution is understanding the genetic causes behind phenotypic characteristics of organisms. Such an understanding would mean having a blueprint which specifies the exact ways in which genetic components, like genes and proteins, interact to make a complex living system. The availability of genome-wide gene expression technologies has made at least a part of this goal closer, that of identifying the interactions between genes in a living system, or gene networks. Well suited for both qualitative and quantitative level modeling and simulation, and thus embraced by both biologists and computational scientists, gene networks have the potential to elucidate the effect of the nature and topology of interactions on the systemic properties of organisms.