ABSTRACT

Introduction..............................................................................................................53 4.1 Comparison of Features of the 10-23 DNA Enzyme and Other

Gene-Silencing Agents...................................................................................54 4.1.1 Chemical Composition, Production, Delivery, and Stability ............54 4.1.2 Target Limitations, Specificity, and Activity .....................................55

4.2 Mechanism of the 10-23 DNA Enzyme........................................................57 4.3 How RNA-Cleaving DNA Enzymes Are Selected .......................................60 4.4 Parameters That Could Affect the Catalytic Activity of Selected