ABSTRACT
The majority of the studies on toxicology and temperature regulation involve short-term, acute responses in laboratory rodents. This chapter focuses on the integrative thermoregulatory responses to toxic insult, including the acute response of laboratory rodents, other mammals, and humans. In many toxicological studies, only body temperature was recorded, with no mention of how the changes in temperature were mediated. This chapter endeavors to explain the integrative thermoregulatory responses, meaning the homeostatic processes that are involved in mediating a change in body temperature. Toxicant-induced changes in body temperature that occur over several days, including febrile responses, are covered in Chapter 6.
