ABSTRACT
Exposure.........................................................................................................66 5.3 Blood as a Surrogate Tissue for Monitoring Gene Expression Changes
in an Inaccessible Target Tissue ....................................................................69 5.3.1 The Evolution of Blood-Based Surrogate Tissue Analysis...............69 5.3.2 Use of DNA Arrays to Monitor Gene Expression in Rat Blood
and Uterus Following 17-b-Estradiol Exposure — Biomonitoring Environmental Effects Using Surrogate Tissues ...............................70
5.4 Challenges to the Use of Blood as a Surrogate Tissue.................................72 5.4.1 Inter-Individual Variation in Gene Expression ..................................72 5.4.2 Technologically Induced Variation in Gene Expression ...................73
5.5 Summary ........................................................................................................73 References................................................................................................................74
