ABSTRACT
Introduction ............................................................................................ 57 Antitoxicants and Chemical Carcinogenesis......................................... 59 Antitoxicants as Sequestrants and Diluents ......................................... 59 Antitoxicants Alter Toxicant Biotransformation and Suppress the Initiation Phase of Carcinogenesis .................................................. 60
Antitoxicant Inducers of Biotransformation Enzymes..................... 61 Antitoxicant Inhibitors of Toxicant Biotransformation .................... 63
Antitoxicants Against the Promotion Phase of Carcinogenesis ........... 64 Antitoxicants as Antioxidants ........................................................... 65 Antitoxicants as Eicosanoid Suppressors ......................................... 66 Antitoxicants as Hormone Antagonists ............................................ 67 Antitoxicants and Post-Translational Modification of Toxicant-Stimulated Proteins............................................................. 68
Conclusions............................................................................................. 69 Acknowledgment ................................................................................... 70 References ............................................................................................... 70
In the U.S., recent assessments of human cancer risks due to exposure to environmental toxicants entering the food supply have shown clearly that industrial, agricultural, and other manufactured environmental contaminants constitute a nearly negligible risk, whereas naturally occurring toxicants in the food supply are of at least minor significance to human cancer risk.
