ABSTRACT
The data suggest genetic factors play an important role in regulating vulnerability to becoming a smoker, but only limited progress has been made in humans in terms of identifying genes critical in regulating nicotine
dependence. However, some progress has been made in understanding the regulation of responses to nicotine in the mouse. This chapter will outline strategies that have been, or could be, used to identify genes that regulate behaviors. Specific examples of how these strategies have been used to gain an understanding of genetic influences on nicotine-related behaviors will be provided.
