ABSTRACT
To validate an analytical method, it is necessary to take into account the quality, reliability, selectivity, and sensitivity of the method, and also its suitability for the particular types of samples. It can happen that the same method may be validated for clinical analysis, but not for environmental analysis. Always one must keep in mind that the method validation is related to the type and complexity of the matrix. Each method must be validated in part for the determination of a specific analyte in a specific type of matrix.
