ABSTRACT

Regulators of Cell Growth .................................................18 2.2.2 Molecular and Cellular Events during Initiation and Promotion

of Carcinogenesis ...............................................................................18 2.2.2.1 Activation of Oncogenes ....................................................18 2.2.2.2 Inactivation of Tumor Suppressor Genes ...........................20 2.2.2.3 Alteration of Genes Regulating Apoptosis.........................21

2.2.3 Molecular and Cellular Events during Progression of Carcinogenesis ...................................................................................22