ABSTRACT

Introduction ...................................................................................................................................... 1 Vaccine Development Technologies ................................................................................................ 3

First-Generation Vaccines....................................................................................................... 4 Second-Generation Vaccines .................................................................................................. 4 Third-Generation Vaccines ..................................................................................................... 4 Adjuvants ................................................................................................................................ 5

The Historical Role of Animal Models in Vaccinology.................................................................. 5 Characteristics of the Use of Laboratory Animals in Vaccinology ................................................ 7 Animal Models in Vaccinology ....................................................................................................... 8

Animal Models in Vaccine Development .............................................................................. 8 Animal Models in Vaccine Production ................................................................................ 10 Animal Models in Vaccine Quality Control ........................................................................ 11

Conclusion...................................................................................................................................... 13 References ...................................................................................................................................... 13

INTRODUCTION

Vaccines belong to the category of immunobiologicals — products that are produced by or derived from a living organism. Immunobiologicals include a variety of products, such as vaccines, immunoglobulins, monoclonal antibodies, and antisera. The characteristic feature of vaccines is that these preparations are capable of inducing a specific and active immunity against an infecting agent or its toxin.