ABSTRACT
Early neural modelers (in the 1960s) were faced with a dilemma. Digital computers of that era were not user-friendly as tools for interactive modeling, and analog computers were also unwieldy. Also, far less was known about the behavior of specific ionic conductances and transmembrane proteins in determining the observable electrical phenomena of neuronal transmembrane voltage. Thus, many neural modelers in the 1960s developed dedicated, compact transistor circuits to emulate spike generation, and various nonlinear RC low-pass networks to model the generation of epsps and ipsps, and signal conduction on dendrites.
