ABSTRACT
I. Introduction: Relevance of Glutamate to Schizophrenia .....................................................121 II. Glutamate Receptors .............................................................................................................122 III. Amino Acid Concentrations in Schizophrenia .....................................................................123 IV. Amino Acid Receptors in Schizophrenia .............................................................................123 V. Phencyclidine and Ketamine.................................................................................................124 VI. Antipsychotic Agents Modulate NMDA Antagonist Effects ...............................................126 VII. Antipsychotic Drugs and Amino Acid Concentrations in Serum, Brain, and CSF ............127 VIII. Clinical Trials with Glutamatergic Agents ...........................................................................129
