Luciferase Assay: A Powerful Tool to Determine Toxic Metal–Induced NF-κB Activation

B Activation.........................................................................232 16.2.1 General Pathway of NF-

κ

B Activation ................................................................232 16.2.2 MEKK1 .................................................................................................................233 16.2.3 NF-

κ

B-Inducing Kinase (NIK) ............................................................................234 16.2.4 NF-

κ

B Activating Kinase (NAK).........................................................................234 16.2.5 Akt .........................................................................................................................235 16.2.6 Mixed-Lineage Kinase 3 (MLK3) ........................................................................236