ABSTRACT
Chronic alcoholism is associated with significant widespread shrinkage of brain parenchyma, preferentially affecting the frontal lobes and partially reversible with abstinence. However, even long-abstinent alcoholics exhibit residual tissue volume
deficit, leading to the hypothesis that alcohol-related abnormalities comprise both reversible and permanent components (Carlen et al., 1984; Harper, 1998; Lishman, 1990; Ron, 1987).
