ABSTRACT

I. Epidemiological Studies ...............................................................................244 II. Molecular and Metabolic Aspects of Coronary Heart Disease ...................245

A. Introduction.......................................................................................245 B. Endothelial Injury .............................................................................246 C. Lipid Infiltration and Accumulation.................................................247 D. Endothelial Rupture and Thrombosis...............................................249 E. Dietary Determinants of Atherosclerosis and Newly

Emerging Risk Factors .....................................................................249 III. Genetic Predisposition Of Coronary Heart Disease and the

Role of Gene-Diet Interactions....................................................................250 A. Introduction.......................................................................................250 B. Apolipoprotein E and Cholesteryl Ester Transfer Protein...............250 C. Lipoprotein(a) and Low Density Lipoprotein Subclass Patterns.....253 D. Homocysteine and Fibrinogen..........................................................254 E. Angiotensin Converting Enzyme......................................................255 F. Conclusion ........................................................................................256

IV. Effects of the Mediterranean Diet on the Development of Coronary Heart Disease ................................................................................................256 A. Olive Oil ...........................................................................................256