ABSTRACT
Introduction .......................................................................................................107 Obesity Epidemic and Its Solutions .................................................................108 Type 2 Diabetes Mellitus and Obesity: “Diabesity” ........................................111 Metabolic Syndrome: Pre-Diabetes or Cardiometabolic Risk? .......................111 Nutrigenetics of Type 2 Diabetes Mellitus.......................................................113 Beta Cell Failure and Type 2 Diabetes Mellitus ..............................................115 Adipokines ........................................................................................................116 Conclusion.........................................................................................................118 References .........................................................................................................118
The traditional medical paradigm for understanding diabetes mellitus has undergone a major shift in the past two decades with the discovery of the many immunological functions of fat cells, especially those located in the mesenteric or visceral fat of the abdomen. This shift in thinking occurred in the molecular-genetic era of the last decade, beginning with the discovery of leptin.
