ABSTRACT
The prevention of cardiovascular disease requires a global approach to risk factor reduction. The benet of targeting multiple risk factors has been reported in several recent trials [1, 2]. A 50% reduction in cardiovascular events can be achieved in diabetic patients with concomitant treatment of hypertension, hyperlipidemia, elevated glucose, smoking, excess weight, poor diet, and lack of exercise [2]. The additive effects of nutrient supplementation on top of standard therapy have been the focus of several recent trials [3, 4]. Omega-3 oils can decrease cardiovascular events when added to usual therapy post-myocardial infarction. A meta-analysis of folate therapy trials reveals a signicant reduction of stroke by 18% [5]. Vitamin D deciency may increase cardiovascular risk factors and cardiac disease. Nutrient supplementation should be considered as part of a global strategy to lower cardiovascular risk.
