ABSTRACT
Biological and biochemical processes rely on networks of molecular interactions. A crucial component of these networks includes proteins, which recognize and associate with one another to perform roles such as cell cycle regulation, signal transduction, and antigen recognition in living organisms. Several systematic experimental techniques, namely, yeast two-hybrid (Fields and Song 1989; Bartel and Fields 1995), mass spectrometry (Gavin, Bosche, et al. 2002; Ho, Gruhler, et al. 2002), protein chips (Zhu, Bilgin, et al. 2001), and phage display (Mullaney and Pallavicini 2001), investigate protein-protein interactions on a genomic scale. These high throughput techniques are rapidly accumulating information on protein-protein interaction.
