ABSTRACT
Proteins recognize and bind to each other through interaction sites. Hence, understanding the mechanisms that underlie protein-protein interaction requires the elucidation of the characteristics of interaction sites. Analysis of interaction sites have revealed some of their commonalities and suggested that it may be possible to identify these sites a priori. Prediction methods that identify protein interaction sites from the structure or even the sequence of a protein will enhance the study of protein-protein interaction, and may break new grounds in protein design and even in the development of drugs.
