His knowledge of Greek enabled him to study the texts of the ancient scholars and physicians and to attempt to reconcile medicine and philosophy in his most famous book known as the Conciliator. This rationalist stance together with his interest in astrology brought d’Abano into conflict with the Catholic Church. In 1315 he was accused of being a heretic and was twice brought before the Inquisition. Acquitted the first time, he died before a second trial was completed and his body was hidden by friends. He was nevertheless found guilty and the Inquisition ordered that his effigy be burned instead.