ABSTRACT
Adhesion is essential in biology. Cell adhesion is required to maintain the structural organization of all multicellular organisms across all anatomical length scales. Cells also transduce mechanical signals and respond by regulating adhesion, motility, and di erentiation. Other adhesive interactions between cells are central to immunity. Pathogens also exploit adhesive interactions with cells to infect hosts. Determining the molecular mechanisms underlying these processes is central to understanding the fundamental basis of a host of biological processes that underlie both the organization of healthy tissues and diseases such as cancer.
