ABSTRACT
There is increasing evidence that numerous chemicals released into the environment by human activities have the potential to alter the normal functions of the endocrine system in wildlife. These xenobiotics are called endocrine disrupting chemicals (EDCs). The aim of this chapter was to catalog the different EDC database resources (biological data, chemical descriptor data, and so forth) available on the Internet for deriving structure-activity models. In vitro and in vivo experimental data from nuclear receptor binding assays, in vitro test methods for detecting EDCs, and comparison between biological assays have been critically analyzed.
