ABSTRACT
Much of the research in toxicology and ecotoxicology is focused on elucidating the mechanisms through which the chemicals exert their adverse effects [1]. Basically, the toxicological effect of a compound to living species depends on its physicochemical properties as well as its concentration and the time of exposure. To fully understand and predict the toxicity of a chemical, it is necessary to consider both its pharmacokinetics (the detailed mechanisms by which chemicals are distributed from the external environment to target tissues) and pharmacodynamics (the detailed mechanisms by which target tissue doses are transformed into adverse biological responses) [2]. This can be done by means of modeling approaches, the combination of pharmacokinetic and pharmacodynamic models allowing us to predict the dose response of an organism to a chemical, based on the exposure concentrations [3].
