ABSTRACT
Enzymes in Mammals ........................................................................ 70 6.2 Distribution of Membrane-Bound SSAO in Mammals .................................. 71
6.2.1 Gene Products ..................................................................................... 71 6.2.2 Tissue and Organ Distribution of SSAO ............................................. 71 6.2.3 Subcellular Distribution ...................................................................... 71
6.3 Major Structural Properties of Human Membrane-Bound SSAO .................. 72 6.4 Catalytic Mechanism of Mammalian Membrane-Bound SSAO .................... 73
6.4.1 Steady State Enzyme Behavior ........................................................... 74 6.5 Substrates ........................................................................................................ 76
6.5.1 Endogenous Substrates ....................................................................... 76 6.5.1.1 Unique Substrates ................................................................ 76 6.5.1.2 Shared Substrates ................................................................. 78
6.5.2 Exogenous Substrates ......................................................................... 79 6.6 Inhibitors ......................................................................................................... 79
6.6.1 SSAO Inhibitors That Also Inhibit Monoamine Oxidase .................. 79 6.6.1.1 Nonhydrazine Substrate Analogues .....................................80 6.6.1.2 Hydrazine-Based Inhibitors .................................................80 6.6.1.3 (Halo)allylamine Derivatives ............................................... 81 6.6.1.4 Miscellaneous Compounds .................................................. 81
6.6.2 SSAO Inhibitors Showing Selectivity in vitro .................................... 82 6.6.2.1 Hydrazine-Based Inhibitors ................................................. 82 6.6.2.2 Nonhydrazine Inhibitors ...................................................... 82
6.7 Assaying SSAO Activity ................................................................................. 83 6.7.1 Radiochemical Assays ........................................................................ 83 6.7.2 Spectroscopic Assays ..........................................................................84
