ABSTRACT
Recommended Screening with Retinoscopy in Diabetes Mellitus Patients Patient Initial Examination Frequency of Follow-Upa
14. In Diabetes Control and Complications Trial (DCCT) patients, glycation and advanced glycation end-product parameters from skin biopsies obtained in 1992 were correlated with retinopathy data from 2004. In a multivariate analysis, glycation and glycoxidation parameters predicted the progression of DR, independent of hemoglobin A1c, which was itself a strong predictor. Thus, glycation of long-lived matrix molecules may explain the effect of intensified insulin treatment on DR progression (Genuth et al., 2005).
