ABSTRACT
The modern history of nonalcoholic fatty liver disease (NAFLD) as a distinct clinical entity has its origins with three independent publications 30 years ago describing liver disease with histologic features similar to those seen with alcohol-related injury, but in patients reliably lacking excessive alcohol consumption.1-3 Many of these patients were obese, glucose intolerant, or had hypertriglyceridemia. In the years that followed, NAFLD has emerged as a substantial cause of liver disease and progress made into understanding the natural history, mechanisms, and treatments of this condition.
