ABSTRACT
Protein function is intimately connected to structure, dynamics, and energy ow, properties that are closely related to each other. Vibrational energy transport, for example, mediates the range of structures proteins maintain for function while serving as an environment for chemical reactions in cells. The anisotropic ow of energy, which is coupled to protein geometry, opens the possibility of energy transport channels between distant sites potentially involved in allostery. Elucidation of networks of channels has become a central goal of computational studies of energy ow in proteins [1-7]. An understanding of thermal ow in proteins is useful in addressing the possibility of conformational change in response to changes in temperature, either due to rapid heating [8] or cooling [9], the latter a particular concern in cryocrystallography.
