ABSTRACT
Adipose tissue is both a classic energy storage organ and also an endocrine-immune organ that regulates homeostasis by secreting a series of hormones and cytokines [1,2]. Inflammatory mediators were once regarded as mainly produced only by the immune system and liver. In 1993, Hotmisligil et al. described direct evidence of an inflammatory process involving adipose tissue by demonstrating the production of tumor necrosis factor-α (TNF-α) by adipose tissue [3].
