Improving the Therapeutic Index through Unusual Routes of Application: Intraarterial Treatment of Liver Metastases

Many efforts have been made to influence the kinetic behavior of drugs and to direct them to specific targets, thus increasing the therapeutic index. The story has been as old as pharmacology, beginning with different ways of drug administration: oral, subcutaneous, intramuscular, and intravenous. Pharmaceutical technology has subsequently been exploited, changing preparations and molecular forms, and using drug linkage and prodrugs.