ABSTRACT

Individual ELINK Risk Assessment Boxes .........................48 4.3.2 Steps in Exposure Calculations .......................................................... 49

4.4 Approaches to Identify the Key Features of the Exposure Prole .................50 4.4.1 Objective 1: Series of Generalized Exposure Proles to Aid

Problem Formulation ..........................................................................50 4.4.2 Objective 2: Identication of Key Characteristics of the

Exposure Pattern ................................................................................. 51 4.4.2.1 Tools to Characterize the Exposure Prole ......................... 53

4.4.3 Objective 3: Guidance Concerning Exposure Regimes in Effects Studies ................................................................................ 53 4.4.3.1 How the Exposure Pattern in the Field May Guide the

Exposure Regime in Effects Studies.................................... 53 4.4.3.2 Toxicological and Ecological Independence of Peaks .........54