ABSTRACT
Cisplatin (CDDP), a remarkable antitumor agent, can cause severe toxicity, especially in the kidney. Free radicals and lipid peroxidation play a role in these toxic effects which is not yet entirely clear. This paper provides an overview of current knowledge about cisplatin-induced changes in antiradicalar systems, especially glutathione and glutathione peroxidase. Cellular alterations and the link between free radicals, cisplatin-induced toxicity, and metallothioneins are considered as well as the means of preventing cisplatin toxicity at the molecular level.
