ABSTRACT
It is an unfortunate but nonetheless realistic observation that the closest the average histopathologist comes to immunologic reagent production is opening the package, throwing away the insert (perhaps after reading it), and possibly rehydrating a lyophilized powder. Ultimately, however, the value of any immunohistologically based diagnosis rests on the quality of the primary antibody reagent probe. No amount of diagnostic perspicacity or sophisticated immunohistochemical technique can repair an irrevocably flawed, or just plain incorrect, tool.
