ABSTRACT

Specific HPLC (5, 6) and GC (7) analytical methods have been described for the determination of praziquantel and its metabolites.

(13). It is extensively metabolized to several mono-and poly-hydroxylated metabolic products (14). The metabolites may have some pharmacological activities (1). The plasma elimination half-life for the unchanged drug is 1 to 1.5 hours and 4 to 5 hours for the metabolites after a single oral dose. Within 24 hours more than 90% of the dose was recovered in the urine as the mono-and poly-hydroxylated metabolites and less than 1% as the parent drug (11, 14, 15).