ABSTRACT
Halogenated acetic acid derivatives are most commonly used as intermediates for synthesis of pharmaceuticals and other industrial chemicals, but halogen substitution gives acetic acid unique properties that have allowed this class of derivatives to be exploited also as reaction catalysts, specialty solvents, and biocides. The halogenated derivatives can be divided into two classes-the acetyl halides and the alpha-halogenated compounds. Acetyl halides typically are used as acetylating reagents in organic synthesis. Alpha-halogenated derivatives, however, have been utilized in a wide variety of applications, including uses as reactive intermediates, catalysts, solvents, and pesticides.
