ABSTRACT
The healing of a wound is among the most complex physiological events that take place after the end of embryological development Locally, wound healing requires a carefully orchestrated response that involves the sequential presence of a variety of cell types within the healing tissue. Once within the wound, these cells must remove nonviable tissue, control infection, revascularize the injured area, and secrete the products necessary for final repair. For these responses to take place at the right times and in the right amounts and proportions, complex and still poorly understood molecular messages must pass from cell to cell. Systemically, appropriate metabolic substrates, including oxygen, and hormonal signaling from the general economy must converge in the wound if the healing process is to succeed.
