ABSTRACT

Thapsigargin, a powerful inhibitor of the Ca2+-ATPases in endoplasmic reticulum (Thastrup et al., 1990) and in sarcoplasmic reticulum (Sagara and Inesi, 1991; Lytton et al., 1991) also stimulates a rapid expression of the c-fos and c-jun protooncogenes (Schönthal et al., 1991c; Schönthal 1992b; Schaefer et al., 1994), presumably by discharging the endoplasmic reticulum Ca2+ stores and increasing the cytoplasmic Ca2+ concentration.