ABSTRACT
LAK S. JE O N G , H E A O . KIM, J . W ARREN BEA CH , W O N K. C H U N G ,+ M O O N W. CHUN,+ a n d C H U N G K. C H U
Department of Medicinal Chemistry, College of Pharmacy, The University of Georgia, Athens, GA 30602 and
f College of Pharmacy, Seoul National University, Seoul, Korea
INTRODUCTION
The discovery of AZT1 as a potent inhibitor of the hum an immunodeficiency virus (HIV) ,2-5 which is the causative agent of AIDS, has led to a renaissance in nucleoside chemistry. Due to this lead com pound, a num ber of nucleoside analogues have been synthesized and evaluated against HIV. From these studies, a num ber of active agents have emerged, which have been developed as potential anti-HIV agents. Furtherm ore, these active nucleosides have become new lead compounds in the search for m ore therapeutically effective agents. In order to discover new agents with m ore potent activity and less toxicity, exhaustive structure-activity relationship studies have been carried out by a num ber of laboratories.
