Predictive modelling of in vivo drug interaction from in vitro data: from theory to a computer-based workbench and its experimental validation

Introduction The variability in the response to drugs is a major difficulty for clinicians, which can potentially induce treatment failure if concentrations are too low, or toxic events if they are too high. Both situations may lead to significant problems, depending on the pharmacological characteristics of the drug (high concentrations and small therapeutic index) and on the type of illness (lack of epilepsy control due to low concentrations).