ABSTRACT
ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; CYP, member of the cytochrome P450 family of enzymes; EM, extensive metaboliser, (phrase originally coined to describe normal metabolism of debrisoquine); G-6-pD, glucose-6-phosphate dehydrogenase; MR, meta bolic ratio, defined as the ratio parent drug/metabolite in urine, indicating phenotype; NAT2, N-acetyltransferase type 2; NAT1, N-acetyltransferase type 1; PM, poor metaboliser (phrase originally coined to describe deficient metabolism of debrisoquine); RFLP, restriction fragment length polymor phism; PCR, polymerase chain reaction.
