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Poole, Poole, and Gunatilleka
DOI link for Poole, Poole, and Gunatilleka
Poole, Poole, and Gunatilleka book
Poole, Poole, and Gunatilleka
DOI link for Poole, Poole, and Gunatilleka
Poole, Poole, and Gunatilleka book
ABSTRACT
The models in Table 1 provide some general insight into the factors that affect the accumulation of neutral solutes in the more organic-rich phase, while illustrating the selectivity of biopartitioning processes. System constants with a positive sign favor accumulation of the solute in the organic-rich phase and those with a negative sign favor accumulation in the water-rich phase. The standout feature of the data in Table 1 is that the m system constant is positive and the b system constant is negative for all distribution systems. This is a reflection of the major contribution to biopartitioning from the high cohesion and hydrogen-bond acidity of water. On the other hand, the significant range of numerical values for the m and b system constants is a measure of the cooperative nature of the organic-rich phase in determining solute behavior. This feature confirms our reservations about assigning hydrophobic properties to compounds, but allows the use of the term lipophilicity when applied to a defined distribution process. In the absence of a defined system, the lipophilic character of a compound cannot be determined, because all possible intermolecular interactions are involved in its assessment and the relative importance of individual interactions depends on the complementary properties of the system considered.