ABSTRACT
Foucault and Chevolot derived a similar approach with a pseudo five solvent system: heptane-methanol (1/1 v/v) associated with MTBE-glyme-water (1:2:1 v/v/v) [2]. The biphasic system composition can be further optimized with another solvent (e.g. a few percent of MTBE in the heptane-DCB-DMF system used to separate the fullerenes enhanced the experimental peak efficiency and the resolution [21]). However, every time a two-solvent system will do the separation, it should be preferred because the phase preparation is the simplest: One solvent is saturated with the other and vice versa. Each phase of most multisolvent biphasic liquid systems contains a different composition of all solvents. It may be difficult to prepare only one phase of such system. Examples of useful two-solvent biphasic liquid system include, in order of decreasing polarity, butanolwater, butanone (MEK)-water, octanol-water, MTBE-water, ethyl acetate-water, toluene-water, heptane-methanol, and heptane-ACN.
